Respiratory Biology and Disease
The CNPRC has been a leader in understanding nonhuman primate lung biology and respiratory disease for more than 30 years. It has the distinction of being the only NIH supported National Primate Research Center with a Respiratory Diseases research unit and scientific expertise in airway immunity, environmental air pollutants, lung physiology, and asthma.
A full suite of physiological endpoints is available to longitudinally assess inhalational safety, therapeutic efficacy, and disease development. We also have advanced inhalation exposure capabilities, including a range of aerosol administration modalities. Both nonhuman primate and rodent models of respiratory disease are supported by our facility.
Examples of Nonhuman Primate Models for Respiratory Biology and Disease include:
- Adult and childhood asthma (Th2 high and Th2 low asthma phenotypes)
- Tobacco and e-cigarette exposures/COPD
- H1N1 influenza infection
- Pulmonary fibrosis
- Wildfire smoke health outcomes