Select Recent Research Highlights
Day JR, Flanagan CL, David A, Hartigan-O'Connor DJ, Garcia de Mattos Barbosa M, Martinez ML, Lee C, Barnes J, Farkash E, Zelinski M, Tarantal AF, Cascalho M, and Shikanov A. Encapsulated Allografts Preclude Host Sensitization and Promote Ovarian Endocrine Function in Ovariectomized Young Rhesus Monkeys and Sensitized Mice. Bioengineering (Basel)10(5):550, 2023. PMCID: PMC10215835
Eid FE, Chen AT, Chan KY, Huang Q, Zheng Q, Tobey IG, Pacouret S, Brauer PP, Keyes C, Powell M, Johnston J, Zhao B, Lage K, Tarantal AF, Chan YA, and Deverman BE. Systematic multi-trait AAV capsid engineering for efficient gene delivery. Nat Commun 15(1):6602, 2024. PubMed Central PMCID: PMC11297966
Gong Y, Moström M, Otero C, Valencia S, Tarantal AF, Kaur A, Permar SR, and Chan C. Mathematical Modeling of Rhesus Cytomegalovirus Transplacental Transmission in Seronegative Rhesus Macaques. Viruses 15:2040, 2023. PMCID: PMC10611067
Hasegawa Y, Kim DHJ, Zhang Z, Taha AY, Capitanio JP, Hogrefe CE, Bauman MD, Golub MS, Van de Water J, VandeVoort CA, Walker CK, and Slupsky CM. Calorie restriction and pravastatin administration during pregnancy in obese rhesus macaques modulates maternal and infant metabolism and infant brain and behavioral development. Front Nutr 10:1146804, 2023. PMCID: PMC10225656
Kim H, Zenhausern R, Gentry K, Lian L, Huayamares SG, Radmand A, Loughrey D, Podilapu AR, Hatit MZC, Ni H, Li A, Shajii A, Peck HE, Han K, Hua X, Jia S, Martinez M, Lee C, Santangelo PJ, Tarantal A, and Dahlman JE. Lipid nanoparticle-mediated mRNA delivery to CD34+ cells in rhesus monkeys. Nat Biotechnol 2024 Nov 22. doi: 10.1038/s41587-024-02470-2. PubMed NIHMSID 2043304
Krueger MR, Fishman-Williams E, Simó S, Tarantal AF, and La Torre A. Expression patterns of CYP26A1, FGF8, CDKN1A, and NPVF in the developing rhesus monkey retina. Differentiation 135:100743, 2024. PMCID: PMC10868720
Kulhankova K, Traore S, Cheng X, Benk-Fortin H, Hallée S, Harvey M, Roberge J, Couture F, Kohli S, Gross TJ, Meyerholz DK, Rettig GR, Thommandru B, Kurgan G, Wohlford-Lenane C, Hartigan-O'Connor DJ, Yates BP, Newby GA, Liu DR, Tarantal AF, Guay D, and McCray P Jr. Shuttle peptide delivers base editor RNPs to rhesus monkey airway epithelial cells in vivo. Nat Commun 14:89051, 2023 PMCID: PMC10698009
Liang SQ, Navia AW, Ramseier M, Zhou X, Martinez M, Lee C, Zhou C, Wu J, Xie J, Su Q, Wang D, Flotte TR, Anderson DG, Tarantal AF, Shalek AK, Gao G, and Xue W. AAV5 Delivery of CRISPR/Cas9 Mediates Genome Editing in the Lungs of Young Rhesus Monkeys. Hum Gene Ther 35 (19-20):814-824, 2024. PubMed Central PMCID: PMC11511778
Pekrun K, Stephens CJ, Gonzalez-Sandoval A, Goswami A, Zhang F, Tarantal AF, Blouse G, and Kay MA. Correlation of antigen expression with epigenetic modifications after rAAV delivery of a human factor IX variant in mice and rhesus macaques. Mol Ther 32(7):2064-2079, 2024. PMCID: PMC11286812
Smith TJ, Elmore ZC, Fusco RM, Hull JA, Rosales A, Martinez M, Tarantal AF, and Asokan A. Engineered IgM and IgG cleaving enzymes for mitigating antibody neutralization and complement activation in AAV gene transfer. Mol Ther 32(7):2080-2093, 2024. PubMed Central PMCID: PMC11286816
Tarantal AF, Noctor SC, and Hartigan-O'Connor DJ. Nonhuman Primates in Translational Research. Annu Rev Anim Biosci 10:441-468, 2022. PMCID: PMC9339229
VandeVoort CA, Chaffin CL, Schall PZ, and Latham KE. Dynamic changes in gene expression of growing nonhuman primate antral follicles. Physiol Genomics 56:764-775, 2024. PMCID: PMC11637489