Nonhuman Primate Models focused on Reproduction, Development, Pregnancy, and Gene Therapy/Somatic Cell Gene Editing
Nonhuman primates and humans share many reproductive and developmental features that emphasize their importance as translational models. The unique expertise of CNPRC Core Scientists provides collaborative opportunities to address research questions associated with all developmental stages (embryo, fetus, newborn, infant), juveniles, young adults, premenopausal/transitional reproductive stages, and advanced geriatrics.
Included are studies that focus on early (prenatal) onset of disease and new therapeutic interventions, regenerative medicine and gene therapy/somatic cell genome editing; lifespan health – from the earliest developmental stages to aging populations; in vivo imaging technologies for precision medicine; and preclinical IND-enabling studies for clinical translation.
Examples of ongoing studies include:
- Viral teratogens and virus trafficking during pregnancy
- Maternal/placental/fetal interactions and microchimerism
- Immune and hematopoietic ontogeny
- Stem cell transplantation and tissue engineering
- Gene Therapy and Somatic Cell Genome Editing (in utero to postnatal)