Pioneering Advances in New Approach Methodologies (NAMs)
For over 35 years, we have pioneered innovation in biomedical research through the use of New Approach Methodologies (NAMs). Our commitment to animal welfare is deeply rooted in the 3Rs principles—Replacement, Reduction, and Refinement—and guided by a profound sense of responsibility. Here at the NBRI, through our commitment to continuous development and expansion of new alternative methods, we are helping build a future that improves health for humans and animals alike, and where more patients gain access to life-saving treatments—swiftly, safely, and with reduced reliance on animal use in research.
New Approach Methodologies include laboratory (in vitro or in chemico) and computer-based (in silico) research. These approaches can transform basic, translational, and clinical science by developing new human-based biomedical research models. This collection of human-relevant tools is used across the biomedical research and development continuum, from discovery and basic research to preclinical testing and regulatory decisions. Instead of relying only on animal models, integrated NAMs can improve translational accuracy, speed up development, reduce costs, and address long-standing ethical concerns.
Through our strategic integration of NAMs and multidisciplinary collaborations with researchers and our involvement with the UC Davis NAMs Testing Center, we continue to foster innovation that enables the creation of next-generation tools and approaches. These solutions not only elevate the quality of research programs offered at the NBRI but also support the shift toward more ethical, sustainable, and scientifically robust research practices.
