Microbial remodeling of gut tryptophan metabolism and indole-3-lactate production regulate epithelial barrier repair and viral suppression in human and simian immunodeficiency virus infections.

Rocha CS, Alexander KL, Herrera C, Weber MG, Grishina I, Hirao LA, Kramer DJ, Arredondo J, Mende A, Crakes KR, Fenton AN, Marco ML, Mills DA, Kappes JC, Smythies LE, Ziprin P, Sankaran-Walters S, Smith PD, Dandekar S. Microbial remodeling of gut tryptophan metabolism and indole-3-lactate production regulate epithelial barrier repair and viral suppression in human and simian immunodeficiency virus infections. Mucosal Immunol. 2025 Jan 31:S1933-0219(25)00011-X. doi: 10.1016/j.mucimm.2025.01.011. Epub ahead of print. PMID: 39894082.