Marcelo J. Kuroda, M.D., Ph.D.
Infectious Disease Unit
Dept. of Anatomy, Physiology, & Cell Biology
School of Veterinary Medicine
Dr. Kuroda’s research program focuses on the important roles of macrophages and neutrophils in the pathogenesis of AIDS, chronic inflammatory diseases and the aging process using the SIV/rhesus macaque model.
AIDS disease pathogenesis and macrophages
Destruction of CD4+ T cells is considered a primary cause of immunodeficiency manifested by opportunistic infections in HIV-1-infected humans, as well as in SIV-infected rhesus macaques. Results from the Kuroda lab demonstrated for the first time that, not only loss of CD4+ T cells, but more importantly macrophage destruction, are keys to the progression and development of AIDS. These studies showed that the AIDS virus massively destroys macrophages but that their decline was not readily evident from blood monocyte levels due to a rapid and efficient feedback from the bone marrow to replenish the destroyed macrophages.