What would you like people to take home from the summary of your work?
Consistent with the human SRS total score, macaque Social Responsiveness Scale-Revised (mSRS-R) total scores are continuously distributed across the general rhesus monkey population. Moreover, mSRS-R total scores robustly and negatively predicted quantitative measures of social behavior. This is the first study to demonstrate that SRS scores in a nonhuman primate species are strongly related to quantitative social behavior measures, confirming that the mSRS-R measures what it was designed to measure (i.e., variation in social behavior) and demonstrating the convergent construct validity of the instrument. Finally, mSRS-R total scores identified the behavioral extremes (low-social and high-social) of a large sample with 96% accuracy, demonstrating the robust predictive validity of the instrument.
These findings indicate that the mSRS-R is a reliable, valid, and sensitive measure of social functioning, and like the human SRS, can be used as a high-throughput screening tool to identify socially impaired individuals in the general population. This instrument will be indispensable for advancing the field’s understanding of the developmental trajectory of core autistic symptomology in rhesus and other macaque monkeys, and it can be used as a primary outcome measure in fast-fail preclinical therapeutic testing efforts.