Animals in Research
Virtually every major medical advance of the last century has relied on animal research. The knowledge gained through such research has led to the ability to treat, prevent or eradicate diseases that once killed millions of people every year. Animal research has also resulted in many lifesaving treatments and therapies for pets and farm animals.
One example of the type of medical advances made possible through animal research is the polio vaccine and other vaccines preventing devastating childhood diseases. These vaccines would not have been possible without testing in laboratory animals. At its peak in the 1950s before vaccinations became available, polio paralyzed or killed an estimated half a million people a year. Today, polio has been virtually eradicated in much of the world.
Why Monkeys
When studying human diseases, nonhuman primates provide one of the best animal models. Humans and monkeys bear a close genetic relationship, reflected in many anatomical, behavioral, developmental, physiological, and reproductive similarities. Monkeys in breeding colonies can live well past their normal lifespan in the wild, providing opportunities for research on aging-related diseases. Because of these close similarities, nonhuman primates have played a critical role in biomedical and behavioral research.
These are many examples of how research in nonhuman primates has extended our fundamental knowledge of how the human body functions in health and disease. Monkeys are susceptible to an immunodeficiency virus similar to HIV, making them ideal for the study of AIDS and potential vaccines and treatments. Similarities in the central motor pathways between monkeys and humans have led to the development of safe and effective interventions to slow the progress of Parkinson’s disease. Monkeys are the only mammalian animal model with menstrual cycles and hormonal patterns comparable to humans, providing crucial insights into fertility, pregnancy and menopause.
Many serious diseases still threaten our well-being: AIDS, Alzheimer’s, cancer and Parkinson’s disease, to name a few. Research toward developing ways to treat and prevent these and other ailments involves the use of animals before the treatments are used in humans, as required by the FDA.
Today more than ever, researchers understand the responsibility that comes with the privilege of working with animals. Their work involves not only a duty to provide a humane environment for their animal subjects, but to minimize the number of animals used, to make their involvement in research as comfortable as possible and to look for alternatives to their use in scientific studies whenever possible.
Nonhuman primates represent only about one third of one percent of animals used in biomedical research.
Humane Care
The California National Primate Research Center is committed to the humane care and use of animals used in research and endorses Russell and Burch’s concepts of the Three R’s. Research proposals using animals provided by the CNPRC address the Three R’s. Studies using animals require prior approval by UC Davis’s Institutional Animal Care and Use Committee (IACUC), which ensures that the project also meets all federal laws governing animal care and use.
In addition, the UC Davis campus, which includes the CNPRC, is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC), a private, nonprofit group that promotes the humane treatment of animals in science through voluntary accreditation. UC Davis is one of more than 770 research institutions and other organizations that have earned AAALAC accreditation, demonstrating its commitment to responsible animal care and use.
The Three R’s
After five years of research for the Universities Federation for Animal Welfare, a scientific animal welfare organization based in the United Kingdom, a book was published in 1959 entitled “The Principles of Humane Experimental Technique” by authors William Russell, a zoologist, and Rex Burch, a microbiologist. They were the first to introduce the concepts of reduction, refinement and replacement, also known as the “Three R’s.”
Russell and Burch maintained that those involved with laboratory animal use have a moral duty to seek replacements to animal experiments whenever possible, keep the numbers of animals used at a minimum and refine procedures to lessen discomfort and stress. They also maintained that good science and animal welfare were inextricably linked. Chronic stress in research animals could result in inaccurate and misleading experimental data, further supporting their call for humane treatment.
These tenets underpin most animal research policy and practice today. They have been incorporated into various U.S. and international laws and embraced by a variety of organizations around the world such as the Center for Alternatives to Animal Testing at Johns Hopkins University and the European Centre for the Validation of Alternative Methods, based in Ispra, Italy. The full text of The Principles of Humane Experimental Technique can be viewed on the Altweb site maintained by the Center for Alternatives to Animal Testing, Johns Hopkins University.
The Three R’s are widely accepted today as the basic principles of good laboratory animal practice. There has been a growing awareness of the need for rigorously designed studies to ensure that such studies can be reproduced. The NIH and the CNPRC are committed to enhancing Rigor and Reproducibility.