Lower urinary tract (LUT) dysfunction is prevalent in older adults. Clinical manifestations include urinary retention, incontinence and recurrent urinary tract infections. Bladder catheters and increased risk for infections requiring outpatient antibiotic treatment or hospitalization frequently result. This is often followed by the loss of independence and the need for [...]
The California National Primate Research Center is pleased to announce the 2023-2024 CNPRC Pilot Research Program recipients. Every year the CNPRC awards pilot research grants focusing on nonhuman primate (NHP) models of human disease. This award aims to explore innovative areas of NHP research and generate preliminary data to [...]
Image of Coppery Titi Monkey. Photo by Kathy West. Monkey Speed-Dating: The Power of First Impressions Just how important are first impressions? Using a speed-dating model, student researcher Alexander Baxter, explored the significance of first impressions in humans and nonhuman primates. The work published in [...]
CNPRC Pilot Research Project Spotlight: The Impact of Age on COVID Response In the spring of 2020, SARS-CoV-2 swept across the world, and scientists everywhere immediately jumped into action. Questions from how the virus spread, to what the infection does to the human body, to who [...]
UC Davis Researchers Awarded $3.5 Million to Study Disease Causing Vision Loss in Children Autosomal dominant optic atrophy (ADOA) is a rare genetic disease that causes progressive and irreversible vision loss in both eyes starting in the first decade of life. There is currently no treatment [...]
The 40th Annual Symposium on Nonhuman Primate Models for AIDS will take place on October 10-13, 2023, at University of California Davis Activities and Recreation Center in Davis, California. Registration is now open! The 40th annual Symposium will be a unique, world-class [...]
Biological and Behavioral Responses to Intranasal Oxytocin A series of studies published by Dr. Karen Bales’ lab at the California National Primate Research Center revealed that chronic intranasal oxytocin (OT) produces sex-specific biological and behavioral responses in titi monkeys, a monogamous nonhuman primate. Karen Bales [...]
Experimental COVID-19 Vaccine Offers Long-Term Protection Against Severe Disease Two-dose vaccines provide protection against lung disease in rhesus macaques one year after they were vaccinated as infants, a new study shows. The work, published in Science Translational MedicineDec. 1, is a follow-up to a 2021 studying [...]
Presence of SARS-CoV-2 in the brain induces neuroinflammation and disruption of the olfactory cortex in rhesus macaques (Danielle Beckman, CNPRC) COVID-19 Virus Infects Neurons, Induces Inflammation in the Brain by Logan Savidge SARS-CoV-2, the COVID-19 virus, caused significant neuron damage and inflammation within [...]
Antibiotic Exposure During Infancy Remodels Immune Response to Respiratory Pathogens Infants are commonly exposed to and treated with antibiotics during the birthing process. However, new research in nonhuman primates may change the way doctors approach antibiotic treatment. A study conducted by the Cincinnati Children’s Hospital Medical Center (CCHMC) [...]
Wildfire Smoke Exposure in Early Pregnancy Affects Infant Monkey Behavior by Andy Fell Infant monkeys conceived while their mothers were naturally exposed to wildfire smoke show behavioral changes compared to animals conceived days later, according to a new study from researchers at the California [...]
Can Early Life Exposure to Wildfire Smoke Alter Our Genes? Early life wildfire smoke exposure led to long-term changes in genes impacting nervous and immune systems in rhesus macaques, according to research from the California National Primate Research Center (CNPRC) at the University of California, Davis. [...]
‘Life of a Neuron’: A Collaboration Between Scientists and Artists UC Davis Faculty Participating in D.C. Exhibition by Logan Savidge We tend to dichotomize the rational approach of scientific methodology and the creativity of artistic expression. However, the two are much more overlapping than we give [...]
Antibody Treatment Prevents Inflammation in Lungs, Nervous System in Macaques With SARS-CoV-2 by Andy Fell Monoclonal antibodies protected aged, diabetic rhesus macaque monkeys from disease due to SARS-CoV-2 and reduced signs of inflammation, including in cerebrospinal fluid, according to a new study from researchers at the University [...]
SARS-CoV-2, the virus responsible for the disease referred to as COVID-19, has swept across the world infecting millions of humans and tragically killing a significant proportion of those infected. COVID-19 has grown from an outbreak to an epidemic and finally a worldwide pandemic at a historic rate. To [...]
Translational animal models are a necessary step to uncovering the biological basis of human disorders like Autism Spectrum Disorder (ASD) which affects 1 in every 54 children in the United States. Kate Talbot, Ph.D. and her colleagues in the Neuroscience and Behavior Unit at the California National Research Primate [...]
A collection of infectious disease researchers at the California National Primate Research Center and the Center for Immunology and Infectious Diseases observed early immune response to SARS-CoV-2 in rhesus macaques. Their findings suggest vaccine developers should focus on promoting specialized immune cells called CD4 T follicular helper (Tfh) cells [...]
Dennis Hartigan-O'Connor, M.D., Ph.D. As scientists rush to find a vaccine for COVID-19, CNPRC core scientist, Dennis Hartigan-O’Connor, M.D., Ph.D is working to optimize vaccine technologies to protect high-risk populations. The University of California Office of the President has awarded Hartigan-O’Connor, along with other scientists across UC [...]
Collaborative efforts from Peter Havel, DVM, PhD with UC Davis and the California National Primate Research Center and Andrew Butler, PhD at the St. Louis School University of Medicine indicate that targeting a protein known as angiopoietin-like protein-3 or ANGPTL3 could be helpful for managing cardiovascular disease. Their results [...]
Lab safety is not the first thing to come to mind when you read about new scientific findings in the news, but it is an integral part of the scientific process. Lab safety not only informs how data is collected, processed, and analyzed, safety protocols allow us to feel [...]
