Jay V. Solnick, M.D., Ph.D.
Infectious Diseases Unit
Department of Microbiology and Immunology
UC Davis School of Medicine
Dr. Solnick has maintained a long-standing research program on the pathogenesis of Helicobacter pylori, using mice and macaque animal models, as well as translational studies in humans. His current work seeks to understand how the bacterium modulates expression of outer membrane protein adhesins and the type IV secretion system, in order to “tune” the host inflammatory response to its own purposes and establish chronic infection.
Most of those infected will not have any clinical disease due to H. pylori infection, and may even be healthier because of it. But about 10% will develop peptic ulcer or gastric cancer, the second most common cause of cancer death worldwide. Therefore, one key goal in the field is to develop biomarkers that can distinguish those who are likely to get ill and need more frequent evaluation, from those who will remain asymptomatic. The Solnick lab has developed an interdisciplinary and international translational project to identify protein and glycan biomarkers that can be used to identify those infected patients at increased risk of gastric cancer.