Anatomic and Clinical Pathology

Primate Anatomic and Clinical Pathology Services (ACPS) has extensive expertise in clinical, gross, and microscopic diagnostic pathology to support multidisciplinary research in human health and disease. It promotes colony health and disease surveillance to ensure the highest level of health in our research animals.

ACPS also provides research support for projects requiring pathology expertise, and maintain and administers valuable resources which are used by an extensive network of investigators at UC Davis, locally, and nationally.

Pathology Capabilities and Resources

Contributing to Human and Animal Health

The pathologists in ACPS are working to characterize common diseases in nonhuman primates to enhance colony health and contribute to veterinary medical knowledge
The staff also identifies and characterizes spontaneous nonhuman primate disease that may be used as models of human disease
They have the ability to integrate information gathered at necropsy with clinical, genetic, and behavioral data, which has the potential to shed new light on the pathogenesis of disease processes, identify phenotypes that may not be immediately apparent with a single discipline approach.

Collaborative Research

ACPS staff also collaborate with investigators within the CNPRC as well as throughout the country to provide pathology support and expertise.

Biospecimen Distribution Program

This program distributes tissue samples as well as other biological samples upon request
Samples can be collected and prepared according to the investigators’ needs
Additionally, a highly organized archive of formalin-fixed and paraffin blocked tissues and glass slides are housed in air conditioned spaces. The catalogued database of this archive allows for easy retrieval of requested samples.

Teaching and Training

Once a month, the ACPS teleconferences with pathologists from other NPRCs and nonhuman primate research institutes from across the country. Unique cases that have occurred in the animals are presented in slides and the case history is discussed
ACPS personnel provide teaching and training across many different sectors, but most notable is the highly sought-after laboratory animal pathology postdoctoral training program in conjunction with the UC Davis School of Veterinary Medicine
The ACPS has an extensive collection of digital images for education

Expertise and Experience

A team of 5 veterinary and anatomic pathologists use their range of collaborative expertise and a total of more than 60 years of combined expertise to provide outstanding pathology services. Additionally, the Clinical Laboratory is headed by a highly experienced medical laboratory scientist who has more than 32 years experience analyzing nonhuman primate samples.

Publications

Chen EC, Yagi S, Kelly KR, Mendoza SP, Tarara RP, Canfield DR, Maninger N, Rosenthal A, Spinner A, Bales KL, Schnurr DP, Lerche NW, and Chiu CY. Cross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colony. PLoS Pathog 7:e1002155, 2011. PMCID: PMC3136464, PMID 21779173

Clay C, J. Reader R, Gerriets J, Wang T, Harrod K, and Miller L. Enhanced viral replication and modulated innate immune responses in infant airway epithelium following H1N1 infection. J Virol 88(13):7412-7425, 2014. PMID 24741104

Jensen K, Ranganathan UD, Van Rompay KK, Canfield DR, Khan I, Ravindran R, Luciw PA, Jacobs WR Jr, Fennelly G, Larsen MH, and Abel K. A recombinant attenuated mycobacterium tuberculosis vaccine strain is safe in immunosuppressed simian immunodeficiency virus-infected infant macaques. Clin Vaccine Immunol 19:1170-1181, 2012. PMCID: PMC3416096

Kanthaswamy S, Reader R, Tarara RP, Oslund K, Allen M, Ng J, Grinberg C, Hyde DM, Smith DG, and Lerche N. Large scale pedigree analysis leads to evidence for founder effects of hypertrophic cardiomyopathy in rhesus macaques (Macaca mulatta). J Med Primatol (in press).

Laing ST, Lemoy M-J, Sammak RL, and Tarara RP. Metastatic hepatocellular carcinoma in a juvenile rhesus macaque (Macaca mulatta). Comp Med 65: 448-453, 2013. PMCID: PMC3796757, PMID 24210023

Lemoy M-J, Lopes DA, Reader R, and Tarara RP. Meningoencephalitis due to Listeria monocytogenes in a pregnant rhesus macaque (Macaca mulatta). J Comp Med 62:443-447, 2012. PMCID: PMC3472610, PMID 23114049

Lemoy M-J, Westworth DR, Ardeshir A, and Tarara RP. Reference intervals for preprandial and postprandial serum bile acid in adult rhesus macaques (Macaca mulatta). J Am Assoc Lab Anim Sc 52:444-447, 2013. PMCID: PMC3725928, PMID 23849441

Luciw PA, Oslund KL, Yang XW, Adamson L, Ravindran R, Canfield DR, Tarara RP, Hirst L, Christensen M, Lerche NW, Offenstein H, Lewinsohn D, Ventimiglia F, Brignolo L, Wisner ER, and Hyde DM. Stereological analysis of bacterial load and lung lesions in nonhuman primates (rhesus macaques) experimentally infected with Mycobacterium tuberculosis. Am J Physiol Lung Cell Mol Physiol 301:L731-L738, 2011. PMCID: PMC3213984, PMID 21873450

Reader JR, Canfield DR, Lane JF, Kanthaswamy S, Ardeshir A, Allen AM, Tarara RP. Left ventricular hypertrophy in rhesus macaques (Macaca mulatta) at the California National Primate Research Center (1992 – 2014). Comparative Medicine 2016;66(2):162-9, PMCID: PMC4825967

Tanaka T and Canfield DR. Intracranial meningioma with ophthalmoplegia in a rhesus macaque (Macaca mulatta). J Comp Med 62:439-442, 2012. PMCID: PMC3472609, PMID 23114048

Trott KA, Chau JY, Hudgens MG, Fine J, Mfalila, CK, Tarara RP, Collins WE, Sullivan J, Luckhart S, and Abel K. Evidence for an increased risk of transmission of Simian Immunodeficiency Virus and malaria in rhesus macaque coinfection model. J Virol 85:11655-11663, 2011. PMCID: PMC3209294, PMID 21917966

Van Rompay KK, Trott KA, Jayashankar K, Geng Y, Labranche CC, Johnson JA, Landucci G, Lipscomb J, Tarara RP, Canfield DR, Heneine W, Forthal DN, Montefiori D, and Abel K. Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal. Retrovirol 9:57. doi: 10.1186/1742-4690-9-57, 2012. PMCID: PMC3419085, PMID 22805180

Zaragoza MM, Sankaran-Walters S, Canfield DR, Hung JK, Martinez E, Ouellette AJ, and Dandekar S. Persistence of gut mucosal innate immune defenses by enteric α-defensin expression in the simian immunodeficiency virus model of AIDS. J Immunol 186:1589-2597, 2011. PMID 21178012