The Challenge of Controlling HIV

A new understanding of how some infants may resist HIV disease When a person is infected with a virus their immune system is normally activated to respond to and control the infection. However, when a person is persistently infected with HIV, the chronic activation and overstimulation of the immune system [...]

Gene therapy treatment shows benefits to Alzheimer’s patients

Gene therapy treatment developed at the CNPRC shows benefits to brain cells for Alzheimer’s patients Reporting on the first-of-its-kind human clinical trials designed to test the potential benefits of nerve growth factor gene therapy for Alzheimer’s patients, Mark Tuszynski, MD, PhD, CNPRC affiliate scientist, has found that an experimental gene [...]

Aging and Synaptic Health

CNPRC Incoming Director John Morrison is expanding our understanding of how estrogen affects cognitive functioning and synaptic health The good, the bad and the ugly. Estrogen; such a familiar hormone, and such a large influence on everyone’s health, female or male, young or old. With an abundance of estrogen during women’s reproductive [...]

Women, Lung Health, and Climate Change

CNPRC research is working to understand the complex issues that affect the lung health of human populations worldwide. There is growing evidence that a number of pulmonary diseases affect women differently, and with a greater degree of severity, than men. There is an urgent need to better understand the potential [...]

MERIT Program Announced at CNPRC

Igniting Novel Research with Current and New Animal Models Drug discovery and innovative therapeutic approaches in the era of personalized medicine requires the use of animal models that closely recapitulate human disease. To address these challenges, the California National Primate Research Center (CNPRC) at UC Davis is initiating the MERIT [...]

Understanding Pre-term Labor for Diagnostics and Therapeutics

Research conducted at the CNPRC on chorioamnionitis-induced preterm labor in women has been recommended by Faculty of 1000, in recognition of the research’s high impact in its field. Faculty of 1000 is a collaboration of over 5,000 world-wide faculty experts who identify important articles in biology and medical research publications. [...]

CNPRC Study Leads to Meningococcal Vaccine Improvements

On February 12, 2015, CNPRC Affiliate Scientists Drs. Koen Van Rompay, Peter Beernink, and Dan Granoff announced important findings from a pilot project study conducted at the CNPRC on improving the effectiveness of the meningococcal vaccine for prevention of sepsis and meningitis caused by meningococci group B, a rare, and sometimes [...]

CNPRC Respiratory Research Supports Lower Ozone Levels

On February 2, 2015, at the invitation of the Environmental Protection Agency (EPA) seeking comments on the optimal level of ozone for public health, Kent Pinkerton, PhD, Core Scientist in the CNPRC Respiratory Diseases Unit and for the Inhalation Exposure Core, presented the scientific basis for requesting that national ozone [...]

2017-10-03T18:21:52+00:00February 26th, 2015|Tags: , , , , , , |

Evaluating Measles Vaccine Safety

High rates of non-vaccinated children throughout the US have reached critical numbers of vulnerable individuals, resulting in perfect conditions for a wildfire storm of measles infections, an easily preventable yet highly contagious disease. More than 120 confirmed cases of measles have been reported in 17 states and the District of [...]

2017-08-30T23:07:09+00:00February 18th, 2015|Tags: , , , , , |

Binge drinking: implications for human health

Think before you drink.
 "Dry January" can be a struggle for some after the holidays, but new research has revealed that you may be benefiting your own and future offspring’s health. A new study by CNPRC Core Scientist Catherine VandeVoort, PhD, (Fetility and Sterility) identified some of the potential effects of long-term [...]

2017-08-30T23:07:09+00:00January 13th, 2015|Tags: , , , , |

Predicting embryo success with in vitro fertilization

According to the American Society for Reproductive Medicine, just 7.5 percent of all artificially fertilized embryos will go on to become live-born children. With such a low success rate, failed in vitro fertilization (IVF) is a frustrating situation for couples and their doctors. Stuart Meyers, D.V.M., Ph.D., CNPRC Affiliate Scientist [...]

Vaccine against HCMV, the “birth defect virus”, produces a strong immune response

An exciting new vaccine strategy was recently announced by Director Peter Barry and colleagues at City of Hope that has the potential to prevent a viral infection that causes 5,000 babies yearly to be born with congenital neurological deficits. Human cytomegalovirus, or HCMV, is a common virus, infecting from 50-100% [...]

Mother’s immunity linked to brain inflammation

Monkeys exposed in utero to their mother’s immune response to a mock infection show inflammation in their brains four years later, similar to which can be associated with schizophrenia and autism. Melissa Bauman presented new findings in her research in brain inflammation in monkeys at the 2014 Society for Neuroscience annual meeting [...]

2017-10-03T18:20:33+00:00November 25th, 2014|Tags: , , , , , |

Loneliness and Health

Monkeys, too, can be lonely, even when surrounded by others in a social group. What is loneliness? Is it wishing to be social but not having friends in your social group? More than just a socio-emotional condition, it can be a significant cause of poor health, and is of special [...]

2017-10-03T18:14:47+00:00November 8th, 2014|Tags: , , , , |

Early HIV infection and potential therapeutic targets

What is potentially exciting about this research is the demonstration that the early stages of gut inflammation and damage can be intervened by the targeted probiotic bacteria. The mucosal lining of the human gastrointestinal tract is on the frontline of immune defenses, crucial in preventing infection and controlling the spread of [...]

2017-08-30T23:07:09+00:00October 30th, 2014|Tags: , , , |

Linking CNPRC research with patients

“For myself and the thousands of people your research efforts may someday impact I want to thank you and wish you the best.” J., CMV patient As a busy Director of both the CNPRC and the Center for Comparative Medicine, Dr. Peter Barry makes time in his hectic schedule to [...]

2017-08-30T23:07:09+00:00October 16th, 2014|

Breast- and Bottle-fed Infant Monkeys Develop Different Immune System

In a study published in Science Translational Medicine on September 3, 2014, researchers from the California National Primate Research Center (CNPRC) at UC Davis and from UC San Francisco have shown that breast-and bottle-fed infant rhesus macaques develop different immune systems. Although the researchers expected that different diets would promote [...]

2017-08-30T23:07:09+00:00September 3rd, 2014|Tags: , , , , , |

Nonhuman Primates and Ebola Virus Treatments and Vaccines

The recent deadly outbreak of Ebola virus in West Africa has highlighted the key role of nonhuman primate biomedical research in developing critically needed treatments and vaccines for emerging infectious diseases. Scientists around the world have pursued different strategies for development of a preventative vaccine and an effective treatment for [...]

2017-08-30T23:07:10+00:00August 6th, 2014|

Improving Models to Understand the Etiology of Autism

Using an exciting, first of its kind method and making great strides in understanding the biology of autism, Sara Freeman, PhD, postdoctoral researcher at the CNPRC, is the first develop a novel protocol using selective oxytocin receptor ligands to locate and map oxytocin receptors in rhesus monkey brains (“The neuroanatomical [...]

2017-08-30T23:07:10+00:00June 25th, 2014|

Why Primate Models Matter

Scientists discuss the importance of primate models for advancing knowledge in biomedical and biological research. Presenting an honest, forthright discussion of the ethical considerations of using nonhuman primates (NHP) in research, and demonstrating the vital role NHP have played in many of the medical and scientific advances of the past [...]

2017-08-30T23:07:10+00:00April 15th, 2014|Tags: , |
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